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Sustainability and affordability of cancer drugs: a novel pricing model

The affordability of newly approved anticancer agents is a challenge to many national health services and reimbursement systems. Therefore, we have developed an approach based upon the adoption of a novel model of price setting and herein provide examples of how it might be implemented. This model is intended to alter the balance between social and economic entrepreneurship.

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Fig. 1: Outline of a proposed new pricing model for cancer drugs.


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Correspondence to Carin A. Uyl-de Groot.

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Competing interests

C.U.-d.G. has received unrestricted grants for research within the Erasmus University from Amgen, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Genzyme, Gilead, Janssen-Cilag, Merck, Roche and Sanofi. B.L. has received personal fees from Agros Pharmaceuticals, Astellas, ASTEX, Celgene, Clear Creek Bio, F. Hoffman-La Roche, Novartis and Seattle Genetics.

Supplementary information

Supplementary file 1 Rationale for adapting the business model of (cancer) drug pricing


Supplementary file 2 Explanation of algorithm of cost price calculation for new (cancer) drugs with an application to enzalutamide and ruxolitinib

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Uyl-de Groot, C.A., Löwenberg, B. Sustainability and affordability of cancer drugs: a novel pricing model. Nat Rev Clin Oncol 15, 405–406 (2018).

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