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The paradox of precision medicine

According to the paradigm of precision medicine, the administration of agents targeting the molecular alteration detected in a particular patient’s tumour reduces uncertainty in the clinical management of that patient. We describe how approaches to precision medicine can lead, paradoxically, to increased levels of uncertainty. We offer recommendations for how physicians can better navigate new uncertainties in precision medicine.

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J.K. is funded by Genome Canada/Genome Quebec (PACEOMICS).

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Correspondence to Jonathan Kimmelman.

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The authors declare no competing interests.

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Kimmelman, J., Tannock, I. The paradox of precision medicine. Nat Rev Clin Oncol 15, 341–342 (2018).

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