Targeted covalent inhibitors (TCIs) can react irreversibly with lysine in kinases and other proteins. Small molecule TCIs can have both broad or specific lysine targeting whereas peptide- and protein-based TCIs were shown to provide high target specificity for lysines in shallow protein surfaces.
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Koperniku, A., Meanwell, N.A. Tying the knot with lysine. Nat Rev Chem 8, 235–237 (2024). https://doi.org/10.1038/s41570-024-00592-4
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DOI: https://doi.org/10.1038/s41570-024-00592-4
