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Surface-enhanced Raman spectroscopy

Pushing the limits

In 1997, Kneipp et al. and Nie and Emory independently reported the first examples of single-molecule detection using surface-enhanced Raman scattering (SERS). These seminal works sparked a surge of interest in SERS, while introducing a new question: how can it be conclusively proven that just one molecule is being probed?

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Fig. 1: Simulated results to demonstrate the evidence for single-molecule detection.


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G.Q.W. acknowledges support from the Leverhulme Trust, RPG-2020-400.

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Correspondence to Duncan Graham.

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Wallace, G.Q., Graham, D. Pushing the limits. Nat Rev Chem 6, 842–843 (2022).

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