Ten years ago, the engineering of a small luciferase called NanoLuc broke through a common limitation of bioluminescence. Currently the brightest known bioluminescent protein, NanoLuc’s activity has been used across a huge application range — enabling measurements in single cells and in whole living organisms.
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The authors declare no competing interests.
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Nagai, T., Hattori, M. Tiny but bright. Nat Rev Chem 6, 522–523 (2022). https://doi.org/10.1038/s41570-022-00413-6
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