Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

FLUXIONAL MOLECULES

Trading places

Pentacoordinate complexes can adopt a variety of structures that are often close in energy, such that the barriers associated with ligands trading places are small. This interconversion is degenerate for homoleptic species such as Fe(CO)5, an archetypical fluxional molecule whose rapid solution-phase dynamics have long eluded spectroscopic quantification. Writing in Organometallics, an international team of Friedrich-Wilhelm Grevels, James Turner, Mike George, Michael Bühl and Peter Portius have now captured these dynamics by collecting infrared spectra and comparing them with simulations that account for coupled vibrations and complex line shapes.

Credit: Carl Conway/Springer Nature Limited

Fe(CO)5 is fluxional because its trigonal bipyramidal (D3h) structure can undergo degenerate Berry pseudorotation, in which two apical ligands take up equatorial positions (and vice versa). This gives back, via a distorted square-pyramidal (C4v) transition state, the same D3h structure and is called a pseudorotation because the net result is rotation about the stationary Fe–Cequatorial bond. Berry pseudorotation in Fe(CO)5 is fast on the nuclear magnetic resonance timescale, with only one 13C signal being present even down to 103 K. Portius’ team instead used infrared spectroscopy at 302–386 K — a temperature range over which Fe(CO)5 remains intact and pseudorotation is accelerated enough to show effects on the infrared timescale. Moreover, these temperatures are amenable to using supercritical Xe as an infrared-transparent solvent that binds negligibly to both D3h and C4v structures so as not to change their relative energies. The spectrum collected at 302 K features bands at ν = 2,026 cm−1 and 2,004 cm−1, which are respectively assigned to asymmetric stretches of axial and equatorial CO ligands — the groups that effectively trade places in the pseudorotation. These bands do not coalesce over the temperature range, so pseudorotation cannot be faster than πΔf/2½ ≈ 1.5 × 1012 s−1f = Δνc; where c = 2.998 × 1010 cm s−1) and must be teased out from the temperature dependence of line broadening.

Simulating the spectra proved to be nontrivial and the team used Voigt functions (convolutions of Gaussian and Lorentzian distributions) to account for the many origins of line-broadening, including the uncertainty principle, Doppler effects from diffusion, as well as collisions. “We simulated the CO-stretching spectral region over the temperature range with an exchange matrix to account for the pseudorotation mechanism, and input force-field parameters, linewidths, vibrational frequencies and pseudorotation rate constants,” says Portius. The rate constants that gave the best-fitting simulations (1.26 × 1011–3.15 × 1011 s−1) follow Arrhenius behaviour and afforded an activation barrier of 2.5 kcal mol−1, a value in agreement with density functional theory predictions.

Fe(CO)5 can now be used as a spectroscopic probe to characterize the nature of, and perhaps quantify, solvent–solute interactions

The dynamics of Fe(CO)5 have vexed chemists but have independently been interrogated using 2D infrared spectroscopy, whereby a vibrational mode is populated with a fast pulse, and, following a delay, an absorption spectrum shows how energy is transferred to other modes. If one varies not only the excitation pulse wavelength but also the delay time, the changes in energy transfer observed with this new technique can unravel dynamics. In comparison, Portius’ study shows how 1D infrared experiments, in combination with careful spectral simulations, afford a more accessible and generalizable approach to challenging problems. Further, by using a solvent that preferentially interacts with one geometry of Fe(CO)5 (for example, by binding the C4v-symmetric form to give a distorted octahedron), it becomes possible to learn about these interactions through the variable-temperature infrared approach. “Our much-improved understanding of the pseudorotation mechanism means that Fe(CO)5 can now be used as a spectroscopic probe to characterize the nature of, and perhaps quantify, solvent–solute interactions in a range of media,” predicts Portius.

References

Original article

  • Portius, P. et al. Structure and dynamics of iron pentacarbonyl. Organometallics 38, 4288–4297 (2019)

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David Schilter.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Schilter, D. Trading places. Nat Rev Chem 4, 2 (2020). https://doi.org/10.1038/s41570-019-0154-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41570-019-0154-7

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing