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Vascular disease

Simvastatin protects against endothelial dysfunction via epigenetic mechanisms

Nature Reviews Cardiology volume 20, page 442 (2023)Cite this article

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Simvastatin improves endothelial cell function by inhibiting endothelial-to-mesenchymal transition (EndMT) through an epigenetic regulatory mechanism, according to a study published in Nature Cardiovascular Research. “Previous studies have shown that statins improve our blood vessels independent of their LDL cholesterol-lowering effects, but the mechanism behind it is not fully understood,” says study investigator Joseph Wu. “Our findings provide a novel epigenetic angle that explains statins’ pleiotropic effects.”

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  1. Nature Reviews Cardiology http://www.nature.com/nrcardio/

    Irene Fernández-Ruiz

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  1. Irene Fernández-Ruiz
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Correspondence to Irene Fernández-Ruiz.

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Fernández-Ruiz, I. Simvastatin protects against endothelial dysfunction via epigenetic mechanisms. Nat Rev Cardiol 20, 442 (2023). https://doi.org/10.1038/s41569-023-00893-z

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  • DOI: https://doi.org/10.1038/s41569-023-00893-z

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