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Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease

IgM antibodies have gained much attention as risk markers of atherosclerotic cardiovascular disease, but the exact antigenic determinants and the full spectrum of functions remain to be defined. A better understanding of the potentially diverse nature of the antigens that they recognize will help to dissect the function of IgM in atherosclerosis.

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Fig. 1: Natural IgM in atherosclerosis.


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C.J.B. was supported by grants from the Austrian Science Fund (FWF SFB F54), the Leducq Foundation (TNE-20CVD03) and the Vienna Science and Technology Fund (LS18-090). The authors thank Dimitrios Tsiantoulas and Florentina Porsch (both at the Medical University of Vienna, Austria) for providing critical comments.

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Correspondence to Christoph J. Binder.

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Deroissart, J., Binder, C.J. Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease. Nat Rev Cardiol 20, 433–434 (2023).

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