IgM antibodies have gained much attention as risk markers of atherosclerotic cardiovascular disease, but the exact antigenic determinants and the full spectrum of functions remain to be defined. A better understanding of the potentially diverse nature of the antigens that they recognize will help to dissect the function of IgM in atherosclerosis.
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C.J.B. was supported by grants from the Austrian Science Fund (FWF SFB F54), the Leducq Foundation (TNE-20CVD03) and the Vienna Science and Technology Fund (LS18-090). The authors thank Dimitrios Tsiantoulas and Florentina Porsch (both at the Medical University of Vienna, Austria) for providing critical comments.
The authors declare no competing interests.
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Deroissart, J., Binder, C.J. Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease. Nat Rev Cardiol 20, 433–434 (2023). https://doi.org/10.1038/s41569-023-00888-w