Excessive salt intake is a known risk factor for cardiovascular disease commonly associated with hypertension. However, we propose that a high-salt diet can promote cardiovascular and other diseases independently of high blood pressure through inflammatory pathways that increase the production of myeloid cells.
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M.K.S.L. (2018214) and A.J.M. (1194329) are supported by investigator grants from the National Health and Medical Research Council of Australia.
The authors declare no competing interests.
World Action on Salt, Sugar and Health: https://www.worldactiononsalt.com/
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Lee, M.K.S., Murphy, A.J. A high-salt diet promotes atherosclerosis by altering haematopoiesis. Nat Rev Cardiol 20, 435–436 (2023). https://doi.org/10.1038/s41569-023-00879-x