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A high-salt diet promotes atherosclerosis by altering haematopoiesis

Excessive salt intake is a known risk factor for cardiovascular disease commonly associated with hypertension. However, we propose that a high-salt diet can promote cardiovascular and other diseases independently of high blood pressure through inflammatory pathways that increase the production of myeloid cells.

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Fig. 1: A high-salt diet drives cardiovascular disease through inflammatory haematopoiesis.


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M.K.S.L. (2018214) and A.J.M. (1194329) are supported by investigator grants from the National Health and Medical Research Council of Australia.

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Correspondence to Andrew J. Murphy.

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The authors declare no competing interests.

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World Action on Salt, Sugar and Health:

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Lee, M.K.S., Murphy, A.J. A high-salt diet promotes atherosclerosis by altering haematopoiesis. Nat Rev Cardiol 20, 435–436 (2023).

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