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Gene editing

Base editing of CaMKIIδ shows promise as cardiac therapy

Nature Reviews Cardiology (2023)Cite this article

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CRISPR–Cas9 base editing of Camk2d, which encodes calcium–calmodulin-dependent protein kinase IIδ (CaMKIIδ), protects the heart from ischaemia–reperfusion damage in mice, according to a study published in Science. “For the first time, we are showing that cardiomyocyte-specific ablation of the oxidative activation sites of CaMKIIδ is both achievable and beneficial for cardiac disease in adulthood,” says Simon Lebek, first author of the study. Given that overactivation of CaMKIIδ is involved in several cardiac diseases, including ischaemia–reperfusion injury, heart failure, hypertrophy and arrhythmia, this cardioprotective strategy could potentially be applicable in a broad range of heart conditions.

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Original article

  • Lebek, S. et al. Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease. Science 379, 179–185 (2023)

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Related article

  • Nishiga, M. et al. The use of new CRISPR tools in cardiovascular research and medicine. Nat. Rev. Cardiol. 19, 505–521 (2022)

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  1. Nature Reviews Cardiology http://www.nature.com/nrcardio/

    Irene Fernández-Ruiz

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  1. Irene Fernández-Ruiz
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Correspondence to Irene Fernández-Ruiz.

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Fernández-Ruiz, I. Base editing of CaMKIIδ shows promise as cardiac therapy. Nat Rev Cardiol (2023). https://doi.org/10.1038/s41569-023-00838-6

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  • DOI: https://doi.org/10.1038/s41569-023-00838-6

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