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The need for new clinical trials of old cardiovascular drugs

While there is understandable excitement about the development of new cardiovascular drugs, an unmet and equally important need is to perform new clinical trials of old drugs, including to determine their longer-term effects and if and when they should be discontinued after years of use. New trials of old drugs can inform clinical practice and are much needed.

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Correspondence to Christopher B. Granger.

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Competing interests

C.B.G. has received consulting fees from AbbVie, Abiomed, Alnylam Pharmaceuticals, Anthos, Bayer Corporation, Boehringer Ingelheim, Boston Scientific Corporation, Bristol Myers Squibb, Cardionomics, CeleCor Therapeutics, Janssen Pharmaceutical, Medtronic, Merck, Novo Nordisk, Novartis Pharmaceutical Company, PLX Pharma, Pfizer and Philips. C.B.G. also has salary funded by Duke University grants sponsored by Boehringer Ingelheim, the Food and Drug Administration, Novartis Pharmaceutical Company and Philips. C.B.G. has equity in The other authors declare no competing interests.

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Granger, C.B., Pocock, S.J. & Gersh, B.J. The need for new clinical trials of old cardiovascular drugs. Nat Rev Cardiol 20, 71–72 (2023).

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