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Caffeine consumption and cardiovascular health

Moderate coffee consumption (2–5 cups per day) has been consistently associated with a lower risk of cardiovascular disease in epidemiological studies. For most individuals, a caffeine intake of up to 400 mg per day is safe and moderate coffee consumption can be included as part of a healthy lifestyle.

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Fig. 1: Mendelian randomization using genetic variants that affect caffeine metabolism.


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Correspondence to Rob M. van Dam or Frank B. Hu.

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van Dam, R.M., Hu, F.B. Caffeine consumption and cardiovascular health. Nat Rev Cardiol 19, 429–430 (2022).

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