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Targeted therapies for cardiac diseases

Heart failure is a systemic disease in which neuroendocrine activation, inflammation and metabolic changes can impair cardiac function. In addition, variants in genes encoding sarcomeric proteins can predispose individuals to develop heart failure. The 2022 Gordon Research Conference on Cardiac Regulatory Mechanisms aims to identify novel treatment targets by applying high-resolution approaches to complex cardiac disorders.

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Fig. 1: Established and potential novel targets in heart failure.

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Acknowledgements

C.M. is funded by the German Research Foundation (DFG; Ma 2528/7-1; SFB 894, SFB 1525), the Barth Syndrome Foundation and the Corona Foundation. J.C.T. is funded by the NIH (HL075619, HL107046 and 137375) and the Steven M. Gootter Foundation.

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Correspondence to Christoph Maack.

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C.M. received honoraria as a speaker or consultant from Amgen, AstraZeneca, Bayer, Berlin Chemie, Boehringer Ingelheim, Bristol Myers Squibb, Novartis, Pfizer and Servier. J.C.T. received honoraria as a speaker or consultant from Bristol Myers Squibb, Cytokenetics and MyoKardia.

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Maack, C., Tardiff, J.C. Targeted therapies for cardiac diseases. Nat Rev Cardiol 19, 343–344 (2022). https://doi.org/10.1038/s41569-022-00704-x

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