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Diversity in human genetics studies accelerates discovery and improves health care

A new, very large genome-wide association study has uncovered many novel genetic factors associated with circulating lipid levels. The success of this study came partly from analysing many samples, but mostly from including individuals of non-European ancestry. So, why is studying genetic diversity important and how can it help to fight cardiovascular disease?

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Correspondence to André G. Uitterlinden.

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Beyond 1 Million Genomes:

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium:

Global Lipids Genetics Consortium:

The Genome of Europe:

The Population Architecture using Genomics and Epidemiology (PAGE) study:

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Uitterlinden, A.G. Diversity in human genetics studies accelerates discovery and improves health care. Nat Rev Cardiol 19, 289–290 (2022).

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