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GENETICS

Protein interactomes uncover new genetic causes of CHD

Nature Reviews Cardiology volume 19, pages 284–285 (2022)Cite this article

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A novel strategy to analyse the protein interactomes of transcription factors whose variants cause congenital heart disease (CHD) identifies GLYR1 as a key gene in heart development, according to findings published in Cell. This integrative approach, which combines techniques from genetics, computational biology and proteomics, provides a framework for identifying specific combinations of genetic variants that cause complex diseases such as CHD.

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  1. Nature Reviews Cardiology http://www.nature.com/nrcardio/

    Karina Huynh

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  1. Karina Huynh
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Correspondence to Karina Huynh.

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Huynh, K. Protein interactomes uncover new genetic causes of CHD. Nat Rev Cardiol 19, 284–285 (2022). https://doi.org/10.1038/s41569-022-00688-8

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  • DOI: https://doi.org/10.1038/s41569-022-00688-8

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