Surgical mitral valve repair produces exceptional long-term survival, durable relief from mitral regurgitation, and physiological valve performance. Percutaneous mitral valve repair might prohibit subsequent surgical reconstruction. This finding has important implications, including for patient consent and clinical trial design. The objectives of mitral valve intervention must focus on life expectancy and long-term valve function.
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Feldman, T. et al. Randomized comparison of percutaneous repair and surgery for mitral regurgitation: 5-year results of EVEREST II. J. Am. Coll. Cardiol. 66, 2844–2854 (2015).
Chikwe, J. et al. Mitral surgery after transcatheter edge-to-edge repair: Society of Thoracic Surgeons database analysis. J. Am. Coll. Cardiol. https://doi.org/10.1016/j.jacc.2021.04.062 (2021).
Ibrahim, M. E., Bavaria, J. E. & El-Hamamsy, I. A biological approach to aortic valve disease: durability and survival. Nat. Rev. Cardiol. 17, 754–756 (2020).
Lazam, S. et al. Twenty-year outcome after mitral repair versus replacement for severe degenerative mitral regurgitation: analysis of a large, prospective, multicenter, international registry. Circulation 135, 410–422 (2017).
Levine, R. A. et al. Mitral valve disease—morphology and mechanisms. Nat. Rev. Cardiol. 12, 689–710 (2015).
Sonnenblick, E. H., Napolitano, L. M., Daggett, W. M. & Cooper, T. An intrinsic neuromuscular basis for mitral valve motion in the dog. Circ. Res. 21, 9–15 (1967).
D’Agostino, R. S. et al. The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2019 update on outcomes and quality. Ann. Thorac. Surg. 107, 24–32 (2019).
Otto, C. M. et al. 2020 ACC/AHA guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 143, e35–e71 (2021).
De Bonis, M. et al. Long-term results (≤18 years) of the edge-to-edge mitral valve repair without annuloplasty in degenerative mitral regurgitation: implications for the percutaneous approach. Circulation 130, S19–S24 (2014).
Chikwe, J. Ask the Expert Session: Management of degenerative mitral regurgitation in intermediate risk patients. Presented at the Society of Throacic Surgeons Annual Meeting 2021.
The authors declare no competing interests.
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Ibrahim, M., Hargrove, W.C. Imperatives in mitral valve interventions: long-term survival, valve durability and valve performance. Nat Rev Cardiol 18, 545–546 (2021). https://doi.org/10.1038/s41569-021-00590-9