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Increasing representation and diversity in cardiovascular clinical trial populations

The homogeneity of cardiovascular clinical trial populations limits the generalizability of results and compounds health inequities faced by women, older adults and people of colour. This Comment highlights the importance of diversity in clinical trial populations and describes multifaceted interventions that might help to close the diversity gap in trial enrolment.

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Fig. 1: Increasing the diversity of participants in cardiovascular clinical trials.


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E.D.M. is supported by the Amato Fund in Women’s Cardiovascular Health at Johns Hopkins University School of Medicine. H.G.C.V. is supported by funding from the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada.

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Correspondence to Erin D. Michos.

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Michos, E.D., Van Spall, H.G.C. Increasing representation and diversity in cardiovascular clinical trial populations. Nat Rev Cardiol 18, 537–538 (2021).

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