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Calcific aortic valve disease: turning therapeutic discovery up a notch

Valve replacement is currently the only treatment for calcific aortic valve disease. Studies of an uncommon, genetic form of aortic valve disease have yielded in vitro and mouse models of the disease and a transcriptomic disease signature. Machine learning-driven screens for compounds that normalize this signature promise to enable medical management of aortic valve disease.

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Fig. 1: Small-molecule screen targeting a NOTCH1-suppressed osteogenic gene network.


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W.T.P. is supported by grants R01 HL138571 and UM1 HL098166.

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Correspondence to William T. Pu.

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Wang, S., Pu, W.T. Calcific aortic valve disease: turning therapeutic discovery up a notch. Nat Rev Cardiol 18, 309–310 (2021).

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