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Cardiovascular health concerns in sexual and gender minority populations

Growing evidence indicates that sexual and gender minority populations might be at greater risk of cardiovascular disease than the general population. Additional population and clinical health research is needed to inform the development of tailored, evidence-based interventions to promote the cardiovascular health of sexual and gender minority populations.

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  1. 1.

    National Academy of Sciences, Engineering, and Medicine. Understanding the Well-Being of LGBTQI+ Populations (2020).

  2. 2.

    Caceres, B. A. et al. Assessing and addressing cardiovascular health in LGBTQ adults: a scientific statement from the American Heart Association. Circulation 142, 2747–2757 (2020).

    Article  Google Scholar 

  3. 3.

    Caceres, B. A. et al. A systematic review of cardiovascular disease in sexual minorities. Am. J. Public Health 107, e13–e21 (2017).

    Article  Google Scholar 

  4. 4.

    Azagba, S., Latham, K. & Shan, L. Cigarette, smokeless tobacco, and alcohol use among transgender adults in the United States. Int. J. Drug Policy 73, 163–169 (2019).

    Article  Google Scholar 

  5. 5.

    Streed, C. G. et al. Cardiovascular disease among transgender adults receiving hormone therapy: a narrative review. Ann. Intern. Med. 167, 256–267 (2017).

    Article  Google Scholar 

  6. 6.

    Streed, C. G., Grasso, C., Reisner, S. L. & Mayer, K. H. Sexual orientation and gender identity data collection: clinical and public health importance. Am. J. Public Health 110, 991–993 (2020).

    Article  Google Scholar 

  7. 7.

    Chan, P. S. Invisible gender in medical research. Circ. Cardiovasc. Qual. Outcomes 12, 139–148 (2019).

    Article  Google Scholar 

  8. 8.

    Streed, C. G., Siegel, J. & Davis, J. A. Keeping our promise to LGBTQ+ patients. AAMC (2019).

  9. 9.

    Streed, C. G., Lunn, M. R., Siegel, J. & Obedin-Maliver, J. Meeting the patient care, education, and research missions: academic medical centers must comprehensively address sexual and gender minority health. Acad. Med. (2020).

    Article  PubMed  Google Scholar 

  10. 10.

    National Public Radio, Robert Wood Johnson Foundation & Harvard T.H. School of Public Health. Discrimination in America: Experiences and Views of LGBTQ Americans. (2017).

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B.A.C. is supported by a career development award from the National Heart, Lung, and Blood Institute of the USA. C.G.S. is supported by a career development award from the AHA.

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Correspondence to Billy A. Caceres or Carl G. Streed Jr.

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The authors declare no competing interests.

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Caceres, B.A., Streed, C.G. Cardiovascular health concerns in sexual and gender minority populations. Nat Rev Cardiol 18, 227–228 (2021).

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