Cocoa consumption improves some metrics of walking performance among old patients with peripheral artery disease (PAD), according to a new study in Circulation Research. Investigators of the phase II, double-blind COCOA-PAD trial randomly assigned 44 patients with PAD (mean age 72.3 years) to consume a flavanol-rich cocoa beverage or an identically appearing placebo beverage thrice daily. At the 6-month follow-up, cocoa consumption improved the 6-min walking distance measured 2.5 h after drinking the study beverage by 42.6 m compared with placebo, but did not improve the 6-min walking distance measured 24 h after study beverage intake. Furthermore, cocoa consumption did not alter maximal and pain-free treadmill walking distance or brachial artery flow-mediated dilatation but improved calf muscle perfusion and capillary density compared with placebo.
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McDermott, M. M. et al. Cocoa to improve walking performance in older people with peripheral artery disease: the Cocoa-Pad pilot randomized clinical trial. Circ. Res. https://doi.org/10.1161/CIRCRESAHA.119.315600 (2020)
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Huynh, K. Cocoa might improve walking performance in PAD. Nat Rev Cardiol 17, 266 (2020). https://doi.org/10.1038/s41569-020-0358-z
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DOI: https://doi.org/10.1038/s41569-020-0358-z