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CARDIAC DEVELOPMENT

Mouse gastruloids take heart

Mouse embryonic organoids that model cardiac development ex vivo could be used as a high-throughput, experimentally tractable system to evaluate crucial cell populations and environmental factors that contribute to normal and abnormal cardiogenesis.

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Fig. 1: Gastruloids derived from mouse embryonic stem cells capture early heart development until formation of a primitive heart tube.

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Acknowledgements

The authors thank K. Claiborn (Gladstone Institutes, San Francisco, CA, USA) for editorial assistance and A. Silva (Gladstone Institutes, San Francisco, CA, USA) for assistance with preparing the figure before submission.

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Correspondence to Deepak Srivastava or Todd C. McDevitt.

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Srivastava, D., McDevitt, T.C. Mouse gastruloids take heart. Nat Rev Cardiol 18, 233–234 (2021). https://doi.org/10.1038/s41569-020-00501-4

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  • DOI: https://doi.org/10.1038/s41569-020-00501-4

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