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Clarification of the definition of hypoplastic left heart syndrome

Nature Reviews Cardiology volume 18, pages 147–148 (2021)Cite this article

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There is still no consensus on the anatomical combinations that make up the so-called hypoplastic left heart syndrome. We argue that an intact ventricular septum should now be part of the definition. Addition of this feature is necessary if accurate predictions are to be made about the morphogenesis of the condition.

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Fig. 1: Ventricular morphology in hypoplastic left heart syndrome.

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Acknowledgements

We are indebted to D. Henderson (Newcastle University, UK) and B. Chaudhry (Newcastle University, UK) for their comments made during the preparation of our manuscript.

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Authors and Affiliations

  1. Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, UK

    Robert H. Anderson

  2. Congenital Heart Center, University of Florida, Gainesville, FL, USA

    Diane E. Spicer

  3. Department of Paediatric Cardiac Surgery, Birmingham Women’s and Children’s Hospital, Birmingham, UK

    Adrian Crucean

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  1. Robert H. Anderson
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  2. Diane E. Spicer
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  3. Adrian Crucean
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Correspondence to Robert H. Anderson.

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Anderson, R.H., Spicer, D.E. & Crucean, A. Clarification of the definition of hypoplastic left heart syndrome. Nat Rev Cardiol 18, 147–148 (2021). https://doi.org/10.1038/s41569-020-00500-5

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