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HEART FAILURE

Clonal haematopoiesis induces a pro-inflammatory monocyte phenotype in HF

Nature Reviews Cardiology volume 18, page 74 (2021)Cite this article

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Clonal haematopoiesis driven by mutations in DNMT3A is associated with poor prognosis in patients with heart failure (HF). In a new study, Stefanie Dimmeler and colleagues show that circulating monocytes in patients with HF who are carriers of DNMT3A mutations have a pro-inflammatory transcriptome, leading to cytokine release, adhesion to endothelial cells and interaction with T cells.

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  • Jaiswal, S. & Libby, P. et al. Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease. Nat. Rev. Cardiol. 17, 137–144 (2020)

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  1. Nature Reviews Cardiology http://www.nature.com/nrcardio/

    Gregory B. Lim

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  1. Gregory B. Lim
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Correspondence to Gregory B. Lim.

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Lim, G.B. Clonal haematopoiesis induces a pro-inflammatory monocyte phenotype in HF. Nat Rev Cardiol 18, 74 (2021). https://doi.org/10.1038/s41569-020-00481-5

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  • DOI: https://doi.org/10.1038/s41569-020-00481-5

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