Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

DYSLIPIDAEMIA

GPR146 is a potential new therapeutic target for lipid lowering

Nature Reviews Cardiology volume 17, pages 132–133 (2020)Cite this article

Subjects

Deficiency in the orphan G protein-coupled receptor 146 (GPR146) decreases blood lipid levels and protects against atherosclerosis in mice independently of LDL receptor (LDLR) activity, according to a new study. “Considering that GPR146 is a druggable target, developing small molecules to inhibit GPR146 is potentially an effective strategy to treat hypercholesterolaemia and atherosclerosis,” say study investigators Haojie Yu and Chad Cowan.

“Development of LDL-C-lowering drugs acting independently of LDLR activity is urgently needed,” remark the researchers. This unmet medical need is particularly relevant for patients with homozygous familial hypercholesterolaemia owing to LDLR mutations, who have a suboptimal response to current LDL-C-lowering therapies such as statins and PCSK9 inhibitors, given that the effects of these agents require the upregulation of LDLR activity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

  • Yu, H. et al. GPR146 deficiency protects against hypercholesterolemia and atherosclerosis. Cell 179, 1276–1288.e14 (2019)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Cardiology http://www.nature.com/nrcardio/

    Irene Fernández-Ruiz

Authors
  1. Irene Fernández-Ruiz
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Irene Fernández-Ruiz.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fernández-Ruiz, I. GPR146 is a potential new therapeutic target for lipid lowering. Nat Rev Cardiol 17, 132–133 (2020). https://doi.org/10.1038/s41569-019-0328-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41569-019-0328-5

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing