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Long-term follow-up of intensive glycaemic control in type 2 diabetes

In a 15-year follow-up of the VADT study, no differences in major cardiovascular outcomes were found among individuals with type 2 diabetes mellitus who underwent either intensive or standard glucose control. These results indicate that intensification of glycaemic control might not be expected to mitigate the risk of cardiovascular events.

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Fig. 1: Clinical trials on intensive versus standard glycaemic control.


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Correspondence to Darren K. McGuire.

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Competing interests

D.K.M. reports honoraria for trial leadership from AstraZeneca, Boehringer Ingelheim, Eisai, Esperion, GlaxoSmithKline, Janssen, Lexicon, Lilly US, Merck & Co, Novo Nordisk, Pfizer and Sanofi Aventis; and honoraria for consulting for Applied Therapeutics, AstraZeneca, Boehringer Ingelheim, Lilly US, Merck & Co, Metavant, Novo Nordisk, Pfizer and Sanofi Aventis. K.V.P declares no competing interests.

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Patel, K.V., McGuire, D.K. Long-term follow-up of intensive glycaemic control in type 2 diabetes. Nat Rev Cardiol 16, 517–518 (2019).

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