Cell culture-based CRISPR screens have become instrumental in functionally annotating the human genome and identifying cancer dependencies. However, standard culture conditions poorly recapitulate the metabolic environments of tissues and organs. Modelling tumour-associated metabolic conditions opens new opportunities for cancer biology and therapeutic discovery.
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J.Z. is a founder, shareholder and scientific advisor of Quantro Therapeutics GmbH, a shareholder and scientific advisor of Mirimus Inc., and receives research funding from Boehringer Ingelheim. W.P. declares no competing interests.
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Zuber, J., Palm, W. Modelling and deciphering tumour metabolism in CRISPR screens. Nat Rev Cancer (2024). https://doi.org/10.1038/s41568-024-00758-8
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DOI: https://doi.org/10.1038/s41568-024-00758-8
