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Multiomics-guided cellular immunotherapies

Nature Reviews Cancer volume 23, page 348 (2023)Cite this article

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Cellular immunotherapy with T cells engineered to target specific tumour antigens has shown remarkable efficacy, with frequent complete remissions in haematological cancers. However, these ‘living drugs’ have had very limited success in solid tumours. The failure of engineered T cells to eradicate solid tumours stems, at least in part, from the inability of T cells to overcome cancer-mediated immune suppression, leading to their exhaustion in the hostile tumour microenvironment (TME).

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  1. OverT Bio, New York, NY, USA

    Mateusz Legut

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  1. Mateusz Legut
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Correspondence to Mateusz Legut.

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Competing interests

M.L. is an inventor on patent applications covering OverCITE-seq filed by the New York Genome Center and New York University. M.L. is an employee and shareholder of OverT Bio.

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Legut, M. Multiomics-guided cellular immunotherapies. Nat Rev Cancer 23, 348 (2023). https://doi.org/10.1038/s41568-023-00570-w

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  • DOI: https://doi.org/10.1038/s41568-023-00570-w

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