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Nodal interferon exposure drives tumour-specific tolerance

Nature Reviews Cancer volume 22, page 377 (2022)Cite this article

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Although lymph node (LN) colonization by primary cancer cells is a well-known predictor of metastasis, not all distant metastases are derived from LN-resident cancer cells. Nathan Reticker-Flynn and colleagues explain this seeming inconsistency by showing that exposure to interferons and interactions with immune cells in LNs not only epigenetically rewires cancer cells, by inducing a tumour-intrinsic interferon response programme that increases their metastatic potential, but also generates tumour-specific immune tolerance that promotes metastasis of both the primary tumour and LN-resident cancer cells.

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  1. Nature Reviews Cancer http://www.nature.com/nrc/

    Caroline Barranco

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  1. Caroline Barranco
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Correspondence to Caroline Barranco.

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Barranco, C. Nodal interferon exposure drives tumour-specific tolerance. Nat Rev Cancer 22, 377 (2022). https://doi.org/10.1038/s41568-022-00489-8

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