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THERAPEUTIC RESISTANCE

Taking the path of most resistance

Nature Reviews Cancer volume 21, page 611 (2021)Cite this article

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The response of patients while on therapy, particularly during sequential administration of different classes of cancer drugs, is a largely unexplored phase compared with before therapy and relapse after therapy. This is especially important given the rapidly emerging clinical challenges of low response rates and acquired resistance. Theoretically, one type of therapy, by shaping both the tumour and its microenvironment, could influence the outcome of a subsequent different therapy. With this in mind, the group of Obenauf set out to investigate this phenomenon by mimicking the clinical scenario whereby a targeted therapy (TT) is administered as the first line until acquired resistance develops and the patient is then switched onto immunotherapy.

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Original article

  • Haas, L. et al. Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma. Nat. Cancer 2, 693–708 (2021)

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  1. Nature Reviews Cancer http://www.nature.com/nrc/

    Anna Dart

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  1. Anna Dart
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Correspondence to Anna Dart.

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Dart, A. Taking the path of most resistance. Nat Rev Cancer 21, 611 (2021). https://doi.org/10.1038/s41568-021-00398-2

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  • DOI: https://doi.org/10.1038/s41568-021-00398-2

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