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Clinical tumour sequencing for precision oncology: time for a universal strategy

Nature Reviews Cancer (2018) | Download Citation

Routine, comprehensive molecular characterization of patient tumours has the potential to accelerate therapeutic advances and inform cancer biology. Here, we describe insights from the implementation of an enterprise-wide, prospective clinical sequencing strategy at an academic cancer centre.

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Author information


  1. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    • Michael L. Cheng
    • , David M. Hyman
    •  & David B. Solit
  2. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    • Michael F. Berger
  3. Marie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    • Michael F. Berger
    •  & David B. Solit


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Competing interests

D.B.S. has served in a consulting or advisory role to Loxo Oncology and Pfizer. D.M.H. has served in a consulting or advisory role to Atara Biotherapeutics, Chugai Pharma, CytomX Therapeutics, Boehringer Ingelheim, AstraZeneca, Pfizer and Genentech, and received research funding from AstraZeneca, Puma Biotechnology and Loxo Oncology. M.L.C. and M.F.B. declare no competing interests.

Corresponding author

Correspondence to David B. Solit.

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