Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Tissue dynamics

It takes more than forceful leaders

Migrating cell clusters exhibit finger-like protrusions at the front, attributed to leader cells physically dragging follower cells along. Now, an optogenetics experiment has shown that follower cells must also play a role in protrusion formation.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The mechanism underlying the formation of finger-like protrusions during collective cell migration remains elusive.

References

  1. Rossetti, L. et al. Nat. Phys. https://doi.org/10.1038/s41567-024-02600-2 (2024).

    Article  Google Scholar 

  2. Saffman, P. G. & Taylor, G. Proc. R. Soc. Lond. Ser. Math. Phys. Sci. 245, 312–329 (1958).

    ADS  Google Scholar 

  3. Toner, J. & Tu, Y. Phys. Rev. E 58, 4828–4858 (1998).

    Article  ADS  MathSciNet  Google Scholar 

  4. Nesbitt, D., Pruessner, G. & Lee, C. F. Phys. Rev. E 96, 062615 (2017).

    Article  ADS  Google Scholar 

  5. Omelchenko, T., Vasiliev, J. M., Gelfand, I. M., Feder, H. H. & Bonder, E. M. Proc. Natl Acad. Sci. 100, 10788–10793 (2003).

    Article  ADS  Google Scholar 

  6. Poujade, M. et al. Proc. Natl Acad. Sci. 104, 15988–15993 (2007).

    Article  ADS  Google Scholar 

  7. Kardar, M., Parisi, G. & Zhang, Y.-C. Phys. Rev. Lett. 56, 889–892 (1986).

    Article  ADS  Google Scholar 

  8. Killeen, A., Partridge, B., Bertrand, T. & Lee, C. F. Phys. Rev. Res. 5, 043096 (2023).

    Article  Google Scholar 

  9. Hino, N. et al. Dev. Cell 53, 646–660 (2020).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Chiu Fan Lee.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lee, C.F. It takes more than forceful leaders. Nat. Phys. (2024). https://doi.org/10.1038/s41567-024-02608-8

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41567-024-02608-8

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing