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Tissue biophysics

Symmetry depends on scale in cellular monolayers

The liquid-crystal-like order of cells in epithelial tissues aids rearrangements, but there is disagreement over the dominant liquid crystal phase. Now, a unified approach reveals that two distinct symmetries dominate at different scales.

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Fig. 1: Liquid crystalline order and defects in cell layers.


  1. Armengol-Collado, J.-M. et al. Nat. Phys. (2023).

  2. Friedl, P. & Gilmour, D. Nat. Rev. Mol. Cell Biol. 10, 445–457 (2009).

    Article  Google Scholar 

  3. Saw, T. B. et al. Nature 544, 212–216 (2017).

    Article  ADS  Google Scholar 

  4. Maroudas-Sacks, Y. et al. Nat. Phys. 17, 251–259 (2021).

    Article  Google Scholar 

  5. Duclos, G. et al. Nat. Phys. 13, 58–62 (2017).

    Article  Google Scholar 

  6. Kawaguchi, K. et al. Nature 545, 327–331 (2017).

    Article  ADS  Google Scholar 

  7. Li, Y.-W. & Ciamarra, M. P. Phys. Rev. Mater. 2, 045602 (2018).

    Article  Google Scholar 

  8. Durand, M. & Heu, J. Phys. Rev. Lett. 123, 188001 (2019).

    Article  ADS  Google Scholar 

  9. Halperin, B. I. & Nelson, D. R. Phys. Rev. Lett. 41, 121–124 (1978).

    Article  ADS  MathSciNet  Google Scholar 

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Correspondence to Daniel Beller.

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Beller, D. Symmetry depends on scale in cellular monolayers. Nat. Phys. (2023).

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