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How cells dig a hole for themselves

Epithelial tissues cover our organs and play an important role as physical barriers. The conditions leading to spontaneous hole formation in monolayer epithelia, which challenge epithelial integrity, have now been revealed.

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Fig. 1: Monolayer integrity depends on substrate stiffness.


  1. Bonfanti, A., Duque, J., Kabla, A. & Charras, G. Trends Cell Biol. 32, 537–551 (2022).

    Article  Google Scholar 

  2. Prakash, V. N., Bull, M. S. & Prakash, M. Nat. Phys. 17, 504–511 (2021).

    Article  Google Scholar 

  3. Proag, A., Monier, B. & Suzanne, M. Development 146, dev172577 (2019).

    Article  Google Scholar 

  4. Watson, A. J. M. et al. Ann. N. Y. Acad. Sci. 1165, 135–142 (2009).

    Article  ADS  Google Scholar 

  5. Sonam, S. et al. Nat. Phys. (2022).

    Article  Google Scholar 

  6. Casares, L. et al. Nat. Mater. 14, 343–351 (2015).

    Article  ADS  Google Scholar 

  7. Harris, A. R. et al. Proc. Natl Acad. Sci. USA 109, 16449–16454 (2012).

    Article  ADS  Google Scholar 

  8. Akhmanova, M. et al. Science 376, 394–396 (2022).

    Article  ADS  Google Scholar 

  9. Trepat, X. et al. Nat. Phys. 5, 426–430 (2009).

    Article  Google Scholar 

  10. Saw, T. B. et al. Nature 544, 212–216 (2017).

    Article  ADS  Google Scholar 

  11. Mammoto, A. et al. Nat. Commun. 4, 1759 (2013).

    Article  ADS  Google Scholar 

Download references

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Correspondence to Tatiana Merle or Magali Suzanne.

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The authors declare no competing interests.

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Merle, T., Suzanne, M. How cells dig a hole for themselves. Nat. Phys. 19, 23–24 (2023).

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