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Protein biophysics

Hidden depths of protein folding

Watching a single protein molecule fold for days reveals rare excursions into configurations that were previously hidden from observation by high energy barriers.

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Fig. 1: Probing remote regions of protein folding landscapes with long-duration force spectroscopy measurements.

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Correspondence to Krishna Neupane or Michael T. Woodside.

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Neupane, K., Woodside, M.T. Hidden depths of protein folding. Nat. Phys. 19, 8–9 (2023). https://doi.org/10.1038/s41567-022-01828-0

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