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Reply to: Insufficient evidence for ageing in protein dynamics

Nature Physics volume 17, pages 775–776 (2021)Cite this article

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The Original Article was published on 24 June 2021

replying to I. Goychuk & T. Pöschel Nature Physics https://doi.org/10.1038/s41567-021-01269-1 (2021)

Reference 1 states that we2 claimed that internal motions in single protein molecules exhibit ageing over 13 decades of time. In contrast, our primary conclusion, as expressed in the title, was that over these timescales the dynamics of single protein molecules is non-equilibrium and self-similar2. Notwithstanding, we demonstrate here that protein dynamics does indeed exhibit ageing according to the criteria of ref. 1.

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Fig. 1: Demonstration of ageing in molecular dynamics of PGK.

References

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Author information

Authors and Affiliations

  1. School of Physics and Astronomy and Institute of Natural Sciences, Shanghai Jiao Tong University, Shanghai, China

    Jun Li & Liang Hong

  2. Schroedinger Inc., New York, NY, USA

    Xiaohu Hu

  3. Wiesbaden Business School, RheinMain University of Applied Sciences, Wiesbaden, Germany

    Thomas Neusius

  4. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, USA

    Xiaolin Cheng

  5. UT/ORNL Center for Molecular Biophysics, Oak Ridge National Laboratory, Oak Ridge, TN, USA

    Micholas Dean Smith & Jeremy C. Smith

  6. Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, USA

    Micholas Dean Smith & Jeremy C. Smith

  7. Mathematical bioPhysics Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

    Aljaž Godec

  8. Institute of Physics & Astronomy, University of Potsdam, Potsdam, Germany

    Ralf Metzler

Authors
  1. Jun Li
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  2. Xiaohu Hu
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  9. Jeremy C. Smith
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Contributions

J.L. and L.H. performed the calculations in Fig. 1. All authors planned the research, analysed the results and wrote the manuscript.

Corresponding author

Correspondence to Jeremy C. Smith.

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Li, J., Hu, X., Neusius, T. et al. Reply to: Insufficient evidence for ageing in protein dynamics. Nat. Phys. 17, 775–776 (2021). https://doi.org/10.1038/s41567-021-01270-8

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