BIOCHEMICAL CLOCKS

The cost of synchronization

Synchronization of biochemical oscillators that are responsible for biological rhythms costs free energy. This theoretical result suggests that part of the adenosine triphosphate molecules consumed by a Kai oscillator is necessary for synchronization.

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Fig. 1: Illustration of the exchange reactions that modify the phase of two clocks.

References

  1. 1.

    Zhang, D., Cao, Y., Ouyang, Q. & Tu, Y. Nat. Phys. https://doi.org/10.1038/s41567-019-0701-7 (2019).

  2. 2.

    Dong, G. & Golden, S. S. Curr. Opin. Microbiol. 11, 541–546 (2008).

  3. 3.

    Nakajima, M. et al. Science 308, 414–415 (2005).

  4. 4.

    Strogatz, S. H. Physica D 143, 1–20 (2000).

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Correspondence to Andre C. Barato.

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Barato, A.C. The cost of synchronization. Nat. Phys. 16, 5 (2020). https://doi.org/10.1038/s41567-019-0735-x

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