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MOLECULAR MOTORS

Stronger than they look

An experimental study of living cells suggests that single myosin molecules are capable of generating unusually large forces. The observation is supported by a theoretical model — and demonstrates the complexity of in vivo force generation.

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References

  1. 1.

    Houdusse, A. & Sweeney, H. L. Trends Biochem. Sci. 41, 989–997 (2016).

  2. 2.

    Finer, J. T., Simmons, R. M. & Spudich, J. A. Nature 368, 113–119 (1994).

  3. 3.

    Guilford, W. H. et al. Biophys. J. 72, 1006–1021 (1997).

  4. 4.

    Ishijima, A. et al. Biochem. Biophys. Res. Commun. 199, 1057–1063 (1994).

  5. 5.

    Molloy, J. E., Burns, J. E., Kendrick-Jones, J., Tregear, R. T. & White, D. C. S. Nature 378, 209–212 (1995).

  6. 6.

    Tyska, M. J. et al. Proc. Natl Acad. Sci. USA 96, 4402–4407 (1999).

  7. 7.

    Lohner, J. et al. Nat. Phys. https://doi.org/10.1038/s41567-019-0477-9 (2019).

  8. 8.

    Wolfenson, H. et al. Nat. Cell Biol. 18, 33–42 (2016).

  9. 9.

    Béfahy, S. et al. Langmuir 26, 3372–3375 (2009).

  10. 10.

    Gateva, G. et al. Curr. Biol. 27, 705–713 (2017).

  11. 11.

    Yang, B. et al. Nano Lett. 16, 5951–5961 (2016).

  12. 12.

    Jülicher, F. & Prost, J. Phys. Rev. Lett. 78, 4510–4513 (1997).

  13. 13.

    Holle, A. W. & Engler, A. J. Curr. Opin. Biotechnol. 22, 648–654 (2011).

  14. 14.

    Hersch, N. et al. Biol. Open 2, 351–361 (2013).

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Correspondence to Ralf Kemkemer.

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Fig. 1: Measuring myosin motor forces in situ.