MOLECULAR MOTORS

Stronger than they look

An experimental study of living cells suggests that single myosin molecules are capable of generating unusually large forces. The observation is supported by a theoretical model — and demonstrates the complexity of in vivo force generation.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Measuring myosin motor forces in situ.

References

  1. 1.

    Houdusse, A. & Sweeney, H. L. Trends Biochem. Sci. 41, 989–997 (2016).

    Article  Google Scholar 

  2. 2.

    Finer, J. T., Simmons, R. M. & Spudich, J. A. Nature 368, 113–119 (1994).

    ADS  Article  Google Scholar 

  3. 3.

    Guilford, W. H. et al. Biophys. J. 72, 1006–1021 (1997).

    ADS  Article  Google Scholar 

  4. 4.

    Ishijima, A. et al. Biochem. Biophys. Res. Commun. 199, 1057–1063 (1994).

    Article  Google Scholar 

  5. 5.

    Molloy, J. E., Burns, J. E., Kendrick-Jones, J., Tregear, R. T. & White, D. C. S. Nature 378, 209–212 (1995).

    ADS  Article  Google Scholar 

  6. 6.

    Tyska, M. J. et al. Proc. Natl Acad. Sci. USA 96, 4402–4407 (1999).

    ADS  Article  Google Scholar 

  7. 7.

    Lohner, J. et al. Nat. Phys. https://doi.org/10.1038/s41567-019-0477-9 (2019).

    Article  Google Scholar 

  8. 8.

    Wolfenson, H. et al. Nat. Cell Biol. 18, 33–42 (2016).

    Article  Google Scholar 

  9. 9.

    Béfahy, S. et al. Langmuir 26, 3372–3375 (2009).

    Article  Google Scholar 

  10. 10.

    Gateva, G. et al. Curr. Biol. 27, 705–713 (2017).

    Article  Google Scholar 

  11. 11.

    Yang, B. et al. Nano Lett. 16, 5951–5961 (2016).

    ADS  Article  Google Scholar 

  12. 12.

    Jülicher, F. & Prost, J. Phys. Rev. Lett. 78, 4510–4513 (1997).

    ADS  Article  Google Scholar 

  13. 13.

    Holle, A. W. & Engler, A. J. Curr. Opin. Biotechnol. 22, 648–654 (2011).

    Article  Google Scholar 

  14. 14.

    Hersch, N. et al. Biol. Open 2, 351–361 (2013).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Ralf Kemkemer.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Holle, A.W., Kemkemer, R. Stronger than they look. Nat. Phys. 15, 628–629 (2019). https://doi.org/10.1038/s41567-019-0492-x

Download citation