News & Views | Published:

BIOPHYSICS

Island hopping for cells

Nature Physics (2019) | Download Citation

A two-state hopping experiment combined with a dynamical systems model reveals that cancer cells are deterministically driven across barriers, whereas normal cells cross only with the help of stochastic fluctuations.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Milo, R. & Phillips, R. Cell Biology by the Numbers (Garland Science, 2015).

  2. 2.

    Brückner, D. B. et al. Nat. Phys. https://doi.org/10.1038/s41567-019-0445-4 (2019).

  3. 3.

    Trepat, X. & Sahai, E. Nat. Phys. 14, 671–682 (2018).

  4. 4.

    Ruprecht, V. et al. J. Cell Sci. 130, 51–61 (2017).

  5. 5.

    Codling, E. A., Plank, M. J. & Benhamou, S. J. R. Soc. Interface 5, 813–834 (2008).

  6. 6.

    Pedersen, J. N. et al. Phys. Rev. E 94, 062401 (2016).

  7. 7.

    Danuser, G., Allard, J. & Mogilner, A. Annu. Rev. Cell Dev. Biol. 29, 501–528 (2013).

  8. 8.

    de Beco, S. et al. Nat. Commun. 9, 4816 (2018).

Download references

Author information

Affiliations

  1. Institute for Theoretical Physics, Heidelberg University, Heidelberg, Germany

    • Ulrich S. Schwarz

Authors

  1. Search for Ulrich S. Schwarz in:

Corresponding author

Correspondence to Ulrich S. Schwarz.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/s41567-019-0470-3

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing