Connected development

Mapping cell lineages onto a problem in graph theory suggests that physical principles regulate cell positioning during egg development in the fruit fly — providing an elegant example of how physics can advance our understanding of biology.

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Fig. 1: The geometry of the egg chamber.


  1. 1.

    Imran Alsous, J., Villoutreix, P., Stoop, N., Shvartsman, S. Y. & Dunkel, J. Nat. Phys. (2018).

  2. 2.

    Bastock, R. & St Johnston, D. Curr. Biol. 18, R1082–R1087 (2008).

    Article  Google Scholar 

  3. 3.

    Johnson, N. Canad. J. Math. 18, 169–200 (1966).

    MathSciNet  Article  Google Scholar 

  4. 4.

    Thomson, J. J. Philos. Mag. 7, 237–265 (1904).

    Article  Google Scholar 

  5. 5.

    Murray, J. D. Mathematical Biology (Springer, New York, NY, 2005).

  6. 6.

    Turing, A. Philos. Trans. R. Soc. B 237, 37–72 (1952).

    ADS  Article  Google Scholar 

  7. 7.

    Thom, R. Structural Stability and Morphogenesis (W. A. Benjamin, Reading, MA, 1975).

    Google Scholar 

  8. 8.

    Ramaswamy, S. Annu. Rev. Condens. Matter Phys. 1, 323–345 (2010).

    ADS  Article  Google Scholar 

  9. 9.

    Tkačik, G. & Bialek, W. Annu. Rev. Condens. Matter Phys. 7, 89–117 (2016).

    ADS  Article  Google Scholar 

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Correspondence to Ben D. MacArthur.

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MacArthur, B.D. Connected development. Nature Phys 14, 975–976 (2018).

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