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Cellular diversity heals

Cells in embryonic tissues generate coordinated forces to close small wounds rapidly without scarring. New research shows that large cell-to-cell variations in these forces are a key system feature that surprisingly speeds up wound healing.

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Fig. 1: Feedback mechanisms that both use and regulate actin, myosin and tension heterogeneity to help close epithelial wounds quickly.


  1. 1.

    Bement, W. M., Forscher, P. & Mooseker, M. S. J. Cell Biol. 121, 565–578 (1993).

    Article  Google Scholar 

  2. 2.

    Zulueta-Coarasa, T. & Fernandez-Gonzalez, R. Nat. Phys. (2018).

    ADS  Article  Google Scholar 

  3. 3.

    Bowman, C. L., Gottlieb, P. A., Suchyna, T. M., Murphy, Y. K. & Sachs, F. Toxicon 49, 249–270 (2007).

    Article  Google Scholar 

  4. 4.

    Yang, X. C. & Sachs, F. Science 243, 1068–1071 (1989).

    ADS  Article  Google Scholar 

  5. 5.

    Brock, J., Midwinter, K., Lewis, J. & Martin, P. J. Cell Biol. 135, 1097–1107 (1996).

    Article  Google Scholar 

  6. 6.

    Bement, W. M. & Mandato, C. A. Mol. Biol. Cell 9, 139A (1998).

    Google Scholar 

  7. 7.

    Kiehart, D. P. Curr. Biol. 9, R602–R605 (1999).

    Article  Google Scholar 

  8. 8.

    Wiemann, J. M., Franke, J. D. & Kiehart, D. P. Mol. Biol. Cell 12, 299A (2001).

    Google Scholar 

  9. 9.

    Jacinto, A., Wood, W., Wilson, C., Martinez-Arias, A. & Martin, P. Mol. Biol. Cell 12, 503A (2001).

    Article  Google Scholar 

  10. 10.

    Shannon, E. K. et al. Biophys. J. 113, 1623–1635 (2017).

    ADS  Article  Google Scholar 

  11. 11.

    Tan, Y.-R. et al. Peptides 27, 1852–1858 (2006).

    Article  Google Scholar 

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Correspondence to M. Shane Hutson.

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Hutson, M.S. Cellular diversity heals. Nature Phys 14, 639–641 (2018).

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