News & Views | Published:


A new wrinkle on the brain

Nature Physicsvolume 14pages435436 (2018) | Download Citation

The folded structure of the human brain is a hallmark of our intelligence — an optimized packing of neurons into a confined space. Similar wrinkling in brain-on-a-chip experiments provides a way of understanding the physics of how this occurs.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Karzbrun, E., Kshirsagar, A., Cohen, S. R., Hanna, J. H. & Reiner, O. Nat. Phys. (2018).

  2. 2.

    Spear, P. C. & Erickson, C. A. Dev. Growth Differ. 54, 306–316 (2012).

  3. 3.

    Fernández, V., Llinares-Benadero, C. & Borrell, V. EMBO J. 35, 1021–1044 (2016).

  4. 4.

    Taber, L. A. Curr. Opin. Genetics Dev. 27, 7–13 (2014).

  5. 5.

    Tallinen, T. et al. Nat. Phys. 12, 588–593 (2016).

  6. 6.

    Bayly, P. V., Okamoto, R. J., Xu, G., Shi, Y. & Taber, L. A. Phys. Biol. 10, 016005 (2013).

  7. 7.

    Reillo, I., de Juan Romero, C., García-Cabezas, M. A. & Borrell, V. Cereb. Cortex. 21, 1674–1694 (2011).

  8. 8.

    Timoshenko, S. P. & Gere, J. M. Theory of Elastic Stability 2nd edn (McGraw-Hill, New York, 1961).

  9. 9.

    Colas, J. F. & Schoenwolf, G. C. Dev. Dyn. 221, 117–145 (2001).

  10. 10.

    Smith, J. L. & Schoenwolf, G. C. Cell Tissue Res. 252, 491–500 (1988).

Download references

Author information


  1. Department of Biomedical Engineering and the Department of Mechanical Engineering and Materials Science at Washington University, St Louis, MO, USA

    • Larry A. Taber


  1. Search for Larry A. Taber in:

Corresponding author

Correspondence to Larry A. Taber.

About this article

Publication history


Issue Date


Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing