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Optical nanoscopy turns coherent

The ability to switch fluorophores on and off is key to performing super-resolution nanoscopy. To date, all switching schemes have been based on an incoherent response to the laser field. Now, a nanoscope that uses on–off coherent switching of quantum dots has been demonstrated.

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Fig. 1: Comparison of STED with RAP super-resolution nanoscopy.


  1. Hell, S. W. & Wichmann, J. Opt. Lett. 19, 780–782 (1994).

    Article  ADS  Google Scholar 

  2. Klar, T. A. & Hell, S. W. Opt. Lett. 24, 954–956 (1999).

    Article  ADS  Google Scholar 

  3. Hell, S. W. Science 316, 1153–1158 (2007).

    Article  ADS  Google Scholar 

  4. Moerner, W. E. & Kador, L. Phys. Rev. Lett. 62, 2535–2538 (1989).

    Article  ADS  Google Scholar 

  5. Betzig, E. et al. Science 313, 1642–1645 (2006).

    Article  ADS  Google Scholar 

  6. Kaldewey, T. et al. Nat. Photon. (2018).

  7. Melinger, J. S., Gandhi, S. R., Hariharan, A., Tull, J. X. & Warren, W. S. Phys. Rev. Lett. 68, 2000–2003 (1992).

    Article  ADS  Google Scholar 

  8. Wu, Y. et al. Phys. Rev. Lett. 106, 067401 (2011).

    Article  ADS  Google Scholar 

  9. Simon, C.-M. et al. Phys. Rev. Lett. 106, 166801 (2011).

    Article  ADS  Google Scholar 

  10. Lüker, S. et al. Phys. Rev. B 85, 121302 (2012).

    Article  ADS  Google Scholar 

Download references

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Correspondence to Thomas A. Klar.

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Klar, T.A. Optical nanoscopy turns coherent. Nature Photon 12, 63–65 (2018).

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