Single-molecule detection commonly requires focused laser beams because of the small absorption cross-sections of dye molecules. Now, researchers have shown that thousands of dye molecules in nanoparticles can transfer light excitation to a single acceptor dye, enabling single-molecule detection at sunlight excitation power.
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Acuna, G.P., Tinnefeld, P. Molecule detection with sunlight. Nature Photon 11, 616–618 (2017). https://doi.org/10.1038/s41566-017-0017-z
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DOI: https://doi.org/10.1038/s41566-017-0017-z