Reducing cancer-related deaths can only happen with a better understanding of cancer biology and the development of improved, new therapeutics and delivery mechanisms. Nearly all cancer research is dependent upon the models being used, the model’s accuracy, and appropriate validation and benchmarking. Here the need for such considerations is discussed in line with the goal of the Cancer Moonshot.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Sharpless, N. E. & Singer, D. S. Cancer Cell 39, 889–894 (2021).
Singer, D. S. Nat. Med. 28, 1345–1347 (2022).
Reilly, M. M. & Rossor, A. M. J. Neurol. Neurosurg. Psychiatry 91, 1132–1136 (2020).
Perlman, R. L. Evol. Med. Public Health 2016, 170–176 (2016).
Kleiber, M. Physiol. Rev. 27, 511–541 (1947).
Wong, C. H., Siah, K. W. & Lo, A. W. Biostatistics 20, 366–366 (2019).
Gasparini, G. Int. J. Biol. Marker 23, 63–63 (2008).
Mak, I. W. Y., Evaniew, N. & Ghert, M. Am. J. Transl. Res. 6, 114–118 (2014).
Frangogiannis, N. G. J. Cardiovasc. Aging 2, 22 (2022).
Katt, M. E., Placone, A. L., Wong, A. D., Xu, Z. S. & Searson, P. C. Front. Bioeng. Biotechnol. 4, 12 (2016).
Hosseini, V. et al. Lab Chip 21, 641–659 (2021).
Ingber, D. E. Nat. Rev. Genet. 23, 467–491 (2022).
Silvestri, V. L. et al. Cancer Res. 80, 4288–4301 (2020).
Wong, A. D., Russell, L. M., Katt, M. E. & Searson, P. C. Acs Biomater. Sci. Eng. 5, 633–643 (2019).
Wong, A. D. & Searson, P. C. Cancer Res. 74, 4937–4945 (2014).
Wong, A. D. & Searson, P. C. Cancer Res. 77, 6453–6461 (2017).
Russell, W. M. S. & Burch, R. L. The Principles of Humane Experimental Technique (Methuen, 1959).
Baran, S. W. et al. Altex-Altern Anim. Ex. 39, 297–314 (2022).
Ekert, J. E. et al. SLAS Discov. 25, 1174–1190 (2020).
Baker, M. Nature 533, 452–454 (2016).
Nosek, B. A. & Errington, T. M. eLife 6, e23383 (2017).
The author declares no competing interests.
About this article
Cite this article
Searson, P.C. The Cancer Moonshot, the role of in vitro models, model accuracy, and the need for validation. Nat. Nanotechnol. 18, 1121–1123 (2023). https://doi.org/10.1038/s41565-023-01486-0