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DNA nanotechnology

Shaken, not heated: DNA self-assembly at room temperature

DNA-origami nanostructures self-assembled at milder physicochemical parameters in magnesium-free conditions achieve structural complexities akin to those formed by thermal annealing at elevated temperatures, and open a route to assembling DNA nanomachines in physiological conditions.

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Fig. 1: DNA-origami fabrication in TANa buffer.


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Correspondence to Elisa Franco.

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Franco, E. Shaken, not heated: DNA self-assembly at room temperature. Nat. Nanotechnol. 18, 1257–1258 (2023).

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