Physico-chemical characteristics of engineered nanomaterials are known to be important in determining the impact on organisms but effects are equally dependent upon the characteristics of the organism exposed. Species sensitivity may vary by orders of magnitude, which could be due to differences in the type or magnitude of the biochemical response, exposure or uptake of nanomaterials. Synthesizing conclusions across studies and species is difficult as multiple species are not often included in a study, and differences in batches of nanomaterials, the exposure duration and media across experiments confound comparisons. Here three model species, Danio rerio, Daphnia magna and Chironomus riparius, that differ in sensitivity to lithium cobalt oxide nanosheets are found to differ in immune-response, iron–sulfur protein and central nervous system pathways, among others. Nanomaterial uptake and dissolution does not fully explain cross-species differences. This comparison provides insight into how biomolecular responses across species relate to the varying sensitivity to nanomaterials.
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This material is based upon work supported by the National Science Foundation under Grant No. CHE-2001611, the NSF Center for Sustainable Nanotechnology (R.J.H and R.D.K.). The Center for Sustainable Nanotechnology is part of the Centers for Chemical Innovation Program. This project used the UWM Great Lakes Genomics Center sequencing and bioinformatics services. UWM Institutional Animal Care and Use Committee protocols followed 20-21 no. 01 and 20-21 no. 50.
The authors declare no competing interests.
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Curtis, B.J., Niemuth, N.J., Bennett, E. et al. Cross-species transcriptomic signatures identify mechanisms related to species sensitivity and common responses to nanomaterials. Nat. Nanotechnol. 17, 661–669 (2022). https://doi.org/10.1038/s41565-022-01096-2