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Nucleic acid delivery differences across species

Examining nucleic acid delivery in humanized animal models might accelerate nanoparticle optimization and potentially improve clinical translation strategies.

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Fig. 1: Simplified depiction of the path to a clinical trial for a nucleic acid nanoparticle product.


  1. Hatit, M. Z. C. et al. Nat. Nanotechnol. (2021).

  2. Torchilin, V. P. Pharm. Res. 24, 1–16 (2007).

    CAS  Article  Google Scholar 

  3. Mestas, J. & Hughes, C. C. W. J. Immunol. 172, 2731–2738 (2004).

    CAS  Article  Google Scholar 

  4. Gorochowski, T. E. & Ellis, T. Nat. Biotechnol. 36, 934–935 (2018).

    CAS  Article  Google Scholar 

  5. Huh, D. et al. Science 328, 1662–1668 (2010).

    CAS  Article  Google Scholar 

  6. Vunjak-Novakovic, G., Ronaldson-Bouchard, K. & Radisic, M. Cell 184, 4597–4611 (2021).

    CAS  Article  Google Scholar 

  7. Dahlman, J. E. et al. Proc. Natl Acad. Sci. USA 114, 2060–2065 (2017).

    CAS  Article  Google Scholar 

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Correspondence to Omar F. Khan.

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Khan, O.F. Nucleic acid delivery differences across species. Nat. Nanotechnol. 17, 223–225 (2022).

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