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Cancer cells hijack T-cell mitochondria

Nanotube-mediated acquisition of immune cells’ mitochondria by tumour cells is a novel mechanism for immune evasion that can be pharmacologically targeted to potentiate cancer immunotherapies.

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Fig. 1: Pharmacological blockade of mitochondrial hijacking improves T-cell antitumour immunity.


  1. 1.

    Saha, T. et al. Nat. Nanotechnol. (2021).

  2. 2.

    Bantug, G. R. et al. Nat. Rev. Immunol. 18, 19–34 (2018).

    CAS  Article  Google Scholar 

  3. 3.

    Sukumar, M. et al. Cell Metab. 23, 63–76 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Spees, J. L. et al. Proc. Natl Acad. Sci. USA 103, 1283–1288 (2006).

    CAS  Article  Google Scholar 

  5. 5.

    Berridge, M. et al. Anal. Biochem. 552, 75–80 (2018).

    CAS  Article  Google Scholar 

  6. 6.

    Mohammadalipour, A. et al. Front. Cell Dev. Biol. 8, 1519 (2020).

    Article  Google Scholar 

  7. 7.

    Burt, R. et al. Blood 134, 1415–1429 (2019).

    CAS  Article  Google Scholar 

  8. 8.

    Moschoi, R. et al. Blood 128, 253–264 (2016).

    CAS  Article  Google Scholar 

  9. 9.

    Yu, Y.-R. et al. Nat. Immunol. 21, 1540–1551 (2020).

    CAS  Article  Google Scholar 

  10. 10.

    Pilipow, K. et al. JCI Insight 3, e122299 (2018).

    Article  Google Scholar 

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Correspondence to Luca Gattinoni.

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Competing interests

L.G. has consulting agreements with Lyell Immunopharma, AstraZeneca, Turnstone Biologics, Xcelcyte. L.G. is on the scientific advisory board of Poseida Therapeutics and Kiromic, and a stockholder of Poseida Therapeutics. J.G.B. declares no competing interests.

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Baldwin, J.G., Gattinoni, L. Cancer cells hijack T-cell mitochondria. Nat. Nanotechnol. (2021).

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