Nanotechnology is a key enabling technology with billions of euros in global investment from public funding, which include large collaborative projects that have investigated environmental and health safety aspects of nanomaterials, but the reuse of accumulated data is clearly lagging behind. Here we summarize challenges and provide recommendations for the efficient reuse of nanosafety data, in line with the recently established FAIR (findable, accessible, interoperable and reusable) guiding principles. We describe the FAIR-aligned Nanosafety Data Interface, with an aggregated findability, accessibility and interoperability across physicochemical, bio–nano interaction, human toxicity, omics, ecotoxicological and exposure data. Overall, we illustrate a much-needed path towards standards for the optimized use of existing data, which avoids duplication of efforts, and provides a multitude of options to promote safe and sustainable nanotechnology.
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The datasets described here are available through the Nanosafety Data Interface and the NanoReg2 database (https://search.data.enanomapper.net/projects/nanoreg2). Data generated within NANoREG, NanoReg2 and the omics metadata are publicly available under CC BY-NC-SA 4.0 license. The NanoReg2 generated data is also available as SQL (DOI: 10.5281/zenodo.4713745, accessed 23 April 2021). Data that originate from the projects NanoTEST, ENPRA, MARINA and NANOGENOTOX are currently restricted from public use.
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The work leading to this article has received funding from the European Union’s Horizon 2020 Research and Innovation programme, Grant Agreements no. 646221 (NanoReg2, 2015–2019), no. 814401 (Gov4Nano, 2019–2022) and no. 814425 (RiskGONE 2019–2023). In addition, the European Union’s 7th Framework Programme projects NANoREG (2013–2017, Grant Agreement no. 310584), NanoTEST (2008–2012, no. 201335) and ENPRA (2009–2012, no. 228789), the European Union’s Health Programme Joint Action project NANOGENOTOX (2010–2013, no. 2009 21 01) and the US NIH NCI caNanoLab portal are acknowledged for providing data.
The authors declare no competing interests.
Peer review information Nature Nanotechnology thanks Wojciech Chrzanowski and Iseult Lynch for their contribution to the peer review of this work.
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Jeliazkova, N., Apostolova, M.D., Andreoli, C. et al. Towards FAIR nanosafety data. Nat. Nanotechnol. 16, 644–654 (2021). https://doi.org/10.1038/s41565-021-00911-6
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